Neuromuscular blockers and ARDS: Thou shalt not breathe, move, or die!

Dracontiasis in antiquity.

Dracontiasis is an infestation of man by the guineaworm, Dracunculus medinensis; a similar infestation also occurs in animals,' and a related species, Dracunculus insignis, is known to infect racoons, mink, and dogs.2 The disease, at the present time, has a wide distribution throughout tropical and subtropical regions ofthe world. The rate of human infestation varies with the possibility of the...

Doctor, thou shalt not kill.

Archimedes’ Cattle Problem

If thou art diligent and wise, O stranger, compute the number of cattle of the Sun, who once upon a time grazed on the fields of the Thrinacian isle of Sicily, divided into four herds of different colours, one milk white, another glossy black, the third yellow and the last dappled. In each herd were bulls, mighty in number according to these proportions: Understand, stranger, that the white bul...

Chronic leg ulcers.

'If you chance to have in Cure an Apostume, that by the malignitie of the humors, or other evill disposition of the body changeth itselfe into a rebellious Ulcer . .. or that such an Ulcer come to thy hand from another Artist, be not out of hope to cure the same. For if Nature be not utterly thy enemy . . . proceeding as followeth, thou shalt be able to cure the disease, by the helpe of God.' J...

Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor.

Mice lacking Musk, a muscle-specific receptor tyrosine kinase that is activated by agrin, fail to form neuromuscular synapses and consequently die at birth because of their failure to move or breathe. We produced mice that express a chimeric receptor, containing the juxtamembrane region of Musk and the kinase domain of TrkA, selectively in muscle, and we crossed this transgene into Musk mutant ...